John Nash won his Nobel for economic models based on game theory. This was the popular attempt to reduce human enterprises to closed-world, zero-sum rational (logical?) models. Subsequent economists have won Nobels for saying that this is simply impossible.
I'm not any sort of expert, but it's just possible that paranoia builds up in a person who tries to build castles of sand on a sand bar. Counter-intuitively, the book suggests he calmed himself by working with computers.